Danielle Potter, Ph.D.
I recently joined the Letai lab after gaining my PhD from the Cancer Research UK Manchester Institute at The University of Manchester. I was previously working in Professor Caroline Dive’s lab on rational drug combinations in the treatment of colorectal and small cell lung cancer. Specifically I was investigating mechanisms to increase the potency of BH3 mimetics which target the Bcl-2 family of proteins which regulate intrinsic apoptosis. I had long followed Professor Letai’s work on BH3 profiling so when the opportunity to work as a postdoc in his lab came up I grabbed it with both hands. I am interested in investigating whether BH3 profiling can be used to identify patient tumor heterogeneity and whether dynamic BH3 profiling on patient biopsies can be used to aid therapeutic decisions. Also I would like to investigate whether BH3 profiling is possible on circulating tumor cells and what this may reveal about the patient and possible treatment options.
I am from Manchester in England which is a great city (I encourage all to visit) but I am excited to be now living in the vibrant city of Boston. I am just finding my way in Boston so in my spare time I am mostly exploring the city and figuring out what other great places I can visit in the states.
Click HERE for my PubMed.